Electron Tomography of Muscle Sarcomere

Laboratory of Pradeep Luther, PhD

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Pradeep Luther BSc PhD

Senior Research Fellow
Molecular Medicine Section
National Heart and Lung Institute
Sir Alexander Fleming Building
Imperial College
Exhibition Road
London SW7 2AZ

Tel 020 7594 3239
Email: p.luther@imperial.ac.uk

 

Michele Chiappi

Research Associate investigating the fine structure of cardiac myosin binding protein C.  Funded by a Programme Grant from the British Heart Foundation.

 

 

Fatima al-Baqali

5th Year MD student from Weill Cornell Medical College in Qatar undertaking research placement investigating transitions of lattice in vertebrate muscle Z-band.

 

 

 

 

Group Alumnii

Steve Hunter BSc

Research Assistant investigating the fine structure of titin kinase by electron tomography of frog skeletal muscle.

 

 

 

 

Iratxe Torre PhD

Research Associate investigating the fine structure of cardiac myosin binding protein C.  Funded by a Programme Grant from the British Heart Foundation.

 

 

 

Sam Cope

3rd Year undergraduate student from University of Exeter.  Sam is undertaking professional training year as part of his Bachlelor of Clinical Sciences degree. 

 

 

 

 

 

Mozhgon Jeddi

3rd Year undergraduate student from University of Exeter on professional training year part of Bachelor of Clinical Science degree.  She will be investigating the ultrastructural changes in cMyBP-C in different states of phosphorylation.

 

 

 

 

Anupama Vydyanath BSc MSc PhD

Research Associate investigating the fine structure of human hypertrophic cardiac muscle due to mutations in cardiac myosin binding protein-C.  Funded by European Commission FP7 award.

 

 

Oday Salim PhD

PhD student - Qualified Jan 2012. Oday investigated the fine structure of striated muscle M-band using electron microscopy and electron tomography.  Successfully defended his thesis on 5 Dec 2011.  Congratulations, Oday!

 

 

 

Thomas Burgoyne BSc PhD

PhD Student - Qualified March 2010.  For his PhD, Tom used electron tomography to investigate the I-band in striated muscle in order to find the mechanism of the transformation of the square lattice at the Z-line to hexagonal in the A-band. 

Following his PhD, Tom worked at the Brompton Hospital investigating the ultrastructure of airway cilia in patients with PCD (primary ciliary dyskinesia).  In May 2011 he took up a post as PostDoc at UCL in the lab of Dr Clare Futter

 

 

Cathy Timson

Electron Microscopist

October 2003-Feb 2008

Expert and experienced electron microscopist, was backbone of the group during these years.

 

 

 

 

Miguel Guerreiro BSc

MPhil on Ultrastructure of Gastric Mucus.  .

 

 

 

 

 

Project students

2012-3

Jonathan Lambert - MRes - obtained Distinction on project

Amina Yonis - MRes - obtained Distinction on project

Alice Mitchell - BSc Biochemistry final year project

Anna Rammou - Bsc Biochemstry final year project

 

2011-2

Naeem Mitha - Medicine

Michael Peacock - Biology

2010-11

Hannah Somani - Biology

Dominic Green - Biology

James Geraets - Physics

Eliza Selley - Physics

 

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